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Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis |
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| Authors: | Revesz Laszlo Bollbuck Birgit Buhl Thomas Eder Joerg Esser Ronald Feifel Roland Heng Richard Hiestand Peter Jachez-Demange Benedicte Loetscher Pius Sparrer Helmut Schlapbach Achim Waelchli Rudolf |
| Institution: | Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Autoimmunity and Transplantation, CH-4002 Basel, Switzerland. Laszlo.revesz@novartis.com |
| Abstract: | Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis. |
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