Effect of specific inhibitors on mitochondrial DNA replication in HeLa cells |
| |
Authors: | L P Mattoccia S Roberti |
| |
Institution: | 1. Department of Biochemical Sciences Princeton University Princeton, New Jersey 08540 USA;2. Department of Biochemistry Michigan State University East Lansing, Michigan 48823 USA |
| |
Abstract: | The crystal structure of an orthorhombic form of 2′-0-methyl cytidine was determined from three dimensional X-ray diffraction data. The two molecules in each asymmetric unit have C2- C3- puckered furanose rings. This differs from the C3- puckering observed for cytidine (1) and it may have some relevance to the kinks that appear at the two 2′-0-methylated nucleotides in the anticodon phosphate ester backbone of the phe tRNA structure (2). This work and other studies (3,4) show that the presence of a 2′-0-methyl group does not prevent the furanose moiety from adopting its most commonly observed configurations. 2′-0-methyl nucleotides make up a small percentage of the residues in HnRNA, rRNA, tRNA and mRNA and therefore their conformational nuances are of interest. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|