Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues |
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Authors: | Sapkota Kiran Roh Eunmiri Lee Eunyoung Ha Eun-Mi Yang Jae-Ho Lee Eung-Seok Kwon Youngjoo Kim Youngsoo Na Younghwa |
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Affiliation: | College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Republic of Korea. |
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Abstract: | In order to develop potent skin whitening agents, we have synthesized 17 hydroxyphenyl benzyl ether compounds and tested their melanin synthesis inhibitory activity, DPPH free radical scavenging activity and tyrosinase inhibitory activity. Compounds 32, 35 and 36 possessing 4-hydroxyphenyl benzyl ether structure showed excellent inhibitory capacity with almost 50-fold than arbutin used as a reference in the inhibition test of α-MSH stimulated melanin synthesis in B-16 cells. 4-Hydroxyphenyl benzyl ether compounds also showed good antioxidant activity in the DPPH free radical scavenging test. The tyrosinase function was effectively inhibited by 3,5-dihydroxyphenyl benzyl ether analogues, especially compounds 18, 22, and 24. |
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