Microwaves synthesis of solid supports for the synthesis of 3'-aminoalkyl oligodeoxynucleotides |
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| Authors: | Goussu Charles Vasseur Jean-Jacques Bazin Hervé Morvan François |
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| Institution: | Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université de Montpellier II, Montpellier Cedex 5, France. |
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| Abstract: | Phthalimido-alkyl alcohol solid supports were rapidly prepared from solid supported phthalic anhydride and amino alcohol condensation induced by microwaves. These supports were used to synthesize 13-aminoalkyl oligodeoxynucleotides allowing a two step deprotection necessary to avoid aminolink alkylation. |
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