白色念珠菌的临床分布及Rosco纸片法药敏结果分析

目的了解目前白色念珠菌的临床分布及其耐药现状，以加强抗真菌药物的合理应用。方法采用Rosco纸片扩散法检测2005年2—9月安徽医科大学第一附属医院临床分离的260株白色念珠菌对7种抗真菌药物的药敏结果。结果白色念珠菌的临床分布以痰液标本为主，老年患者居多。白色念珠菌对制霉菌素、两性霉素B和伊曲康唑的敏感率均较高，分别为98.9％、96．9％和94．2％；其次为酮康唑和氟康唑，敏感率分别为84．6％和82．3％；灰黄霉素、益康唑和眯康唑的敏感率较低，分别为73．9％、57．8％和57．6％。结论临床微生物实验室要加强对白色念珠菌的分离培养和药敏试验，指导临床合理用药，有效控制和减少真菌感染。

Distribution of Candida and analysis of its drug sensitivity by Rosco K-B method

Objective To investigate the distribution and drug resistance of the Candida albicans(C.albicans) and make rational administration of antifungal agents.Method Rosco disc diffusion method was applied for testing the susceptibility of 6 antifungals to 260 strains C.albicans,which were isolated in our hospital from February to September,2000.Results Many of C.albicans originated from spurm sample and old patients.The susceptibility rates of C.albicans to nystatium,amphotericin B,itraconazole,ketoconazole,fluconazole,grseofulvin,ecnazole,miconazole were 98.9%,96.9%,94.2%,84.6%,82.3%,73.9%,57.8% and 57.6%,respectively.Conclusion The isolation of C.albicans and the antifungal sensitivity test should be strengthened in order to guide clinical selection of the reasonable antifungal agents and to control and reduce fungi infeciton.