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Why Helicobacter pylori has Lewis antigens |
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| Authors: | Appelmelk B J Monteiro M A Martin S L Moran A P Vandenbroucke-Grauls C M |
| Institution: | a Dept of Medical Microbiology, Vrije Universiteit, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands b Institute for Biological Sciences, NRC, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6 c GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts, UK SG1 2NY d Dept of Microbiology, University of Galway, University Road, Galway, Ireland. |
| Abstract: | In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization. |
| Keywords: | Helicobacter pylori Lewis blood group antigens lipopolysaccharide phase variation molecular mimicry colonization adhesion |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |