Lysine biosynthesis inMethanobacterium thermoautotrophicum is by the diaminopimelic acid pathway |
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Authors: | Nouna Bakhiet Fred W Forney Donald P Stahly Lacy Daniels |
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Institution: | (1) Department of Microbiology, University of Iowa, 52242 Iowa City, Iowa;(2) Division of Natural Sciences and Mathematics, College of St. Teresa, 55987 Winona, Minnesota, USA |
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Abstract: | Methanobacterium thermoautotrophicum, an archaebacterium, possesses the first and last enzymes of the diaminopimelic acid pathway for lysine biosynthesis, dihydrodipicolinate synthase, and diaminopimelate decarboxylase. It does not have saccharopine dehydrogenase, the last enzyme of the aminoadipate pathway for lysine biosynthesis. The dihydrodipicolinate synthase is inhibited but not repressed by lysine. We conclude that this microbe uses the diaminopimelate pathway for synthesis of lysine.Deceased. |
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