Estimating recombination rates from single-nucleotide polymorphisms using summary statistics |
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Authors: | Padhukasahasram Badri Wall Jeffrey D Marjoram Paul Nordborg Magnus |
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Institution: | Molecular and Computational Biology and Biostatistics Division, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. pkbadri@yahoo.com |
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Abstract: | We describe a novel method for jointly estimating crossing-over and gene-conversion rates from population genetic data using summary statistics. The performance of our method was tested on simulated data sets and compared with the composite-likelihood method of R. R. Hudson. For several realistic parameter values, the new method performed similarly to the composite-likelihood approach for estimating crossing-over rates and better when estimating gene-conversion rates. We used our method to analyze a human data set recently genotyped by Perlegen Sciences. |
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