A catalyst function for MPTP in superoxide formation |
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| Authors: | J Poirier A Barbeau |
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| Affiliation: | 1. RTBioconsultants, Inc., San Diego, CA, USA;2. Departments of Neurology and Developmental Biology, Washington University Medical School, St. Louis, MO, USA |
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| Abstract: | We demonstrate that 1-methyl-4-phenyl-1,2-dihydropyridine (MPDP) can be generated, in an alternate pathway, from the catalyst action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) upon the iron redox equilibrium reaction. Superoxide and ferric iron are instantaneously produced after addition of MPTP to a solution of ferrous iron. This reaction is oxygen and pH dependent. Superoxide, through a iron dependent Haber-Weiss reaction with peroxide, can generate the cytotoxic hydroxyl radical. A small portion of the superoxide reacts with MPTP to produce the reactive species X. which, in the presence of Fe+3 can also generate MPDP. |
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