Toxins of the sea anemone Epiactis prolifera |
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| Authors: | A W Bernheimer L S Avigad |
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| Institution: | 1. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, England;2. Department of Biochemistry, University of London King''s College, Strand, London WC2R 2LS, England |
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| Abstract: | Fe3+-EDTA chelates react with the superoxide radical at physiological pH values (k = 1.3 × 106M?1 s?1 at pH 7 but is lower at more alkaline pH values) but do not appear to catalyze O2? dismutation at a significant rate. Complexes of Fe3+ with desferrioxamine, bathophenanthroline, or diethylenetriaminepentaacetic acid react much more slowly, if at all. Fe2+ complexes of EDTA, ATP, and diethylenetriaminepentaacetic acid also react with O2? at alkaline pH values. The significance of these reactions in the mechanism of the “iron-catalyzed Haber-Weiss reaction” is discussed. |
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| Keywords: | To whom all correspondence should be addressed |
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