| 烟曲霉pbs2基因在热应激与胞壁应激的双重应激中的作用 |
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| 引用本文： | 阳芳,刘伟,万喆,季雅娟,李若瑜.烟曲霉pbs2基因在热应激与胞壁应激的双重应激中的作用[J].中国真菌学杂志,2011,6(4):199-202. |
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| 作者姓名： | 阳芳 刘伟 万喆 季雅娟 李若瑜 |
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| 作者单位： | 北京大学第一医院皮肤性病科,北京大学真菌和真菌病研究中心,北京 100034 |
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| 摘 要： | 目的 通过研究烟曲霉对细胞壁合成干扰物质及棘白菌素类药物的敏感性、烟曲霉在受热应激后HOG通路成分的表达变化探讨pbs2基因在热应激和胞壁应激的双重应激中的作用.方法 烟曲霉野生株AF293和pbs2突变株在含钙荧光白(Calcofluor white,CFW),刚果红(Congo red,CR)和十二烷基硫酸钠(So...
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| 关 键 词： | pbs2 烟曲霉 热应激 胞壁刺激 |
The role of pbs2 gene in the heat stress and cell wall stress of Aspergillus fumigatus |
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| YANG Fang,LIU Wei,WAN Zhe,JI Ya-juan,LI Ruo-yu.The role of pbs2 gene in the heat stress and cell wall stress of Aspergillus fumigatus[J].Chinese JOurnal of Mycology,2011,6(4):199-202. |
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| Authors: | YANG Fang LIU Wei WAN Zhe JI Ya-juan LI Ruo-yu |
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| Institution: | YANG Fang,LIU Wei,WAN Zhe,JI Ya-juan,LI Ruo-yu(Peking University First Hospital,the Research Center for Medical Mycology,Peking University,Beijing 100034) |
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| Abstract: | Objective To verify the role of pbs2 gene in the heat stress and cell wall stress of Aspergillus fumigatus.Methods The sensitivities of AF293 and pbs2 mutant growing on the YAG medium with different concentrations of Calcofluor white,Congo red and Sodium dodecyl sulfate(SDS) to the cell wall interfering compounds and to the echinocandins were observed.The expressions of pbs2 and hog1 gene of AF293 and the pbs2 mutant upon heat stress were detected by Real-time PCR.Results AF293 and the pbs2 mutant showed no... |
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| Keywords: | Aspergillus fumigatus pbs2 heat stress |
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