| 口服特比萘芬联合外用联苯苄唑乳膏治疗足癣长期临床研究 |
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| 引用本文： | 张雅洁,李青.口服特比萘芬联合外用联苯苄唑乳膏治疗足癣长期临床研究[J].中国真菌学杂志,2011,6(4):220-224. |
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| 作者姓名： | 张雅洁 李青 |
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| 作者单位： | 1. 暨南大学第二临床医学院暨深圳市人民医院皮肤科,深圳,518020
2. 深圳市第四人民医院,深圳,518033 |
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| 摘 要： | 目的 为足癣治疗提供较理想的方案.方法 盐酸特比萘芬250 mg,口服1次/d；1%联苯苄唑乳膏,外用1次/d.250例足癣患者随机入组.A组口服1周加外用1周,B组口服1周加外用2周,C组口服2周加外用1周,D组口服2周加外用2周,E组单独外用4周.在治疗结束时、治疗结束后4周、24周、40周、56周、72周时对各组的疗效、复发率进行评价.结果 在停药后第24周时,A、B、C、D组与E组疗效比较差异有统计学意义.在停药后第40周、56周、72周时,D组与A、B组疗效比较差异也出现统计学意义.在停药后24周、40周时,A、B、C、D组真菌学疗效与E组比较差异有统计学意义.在停药56周、72周时,D组与A、B组真菌学疗效比较差异也出现统计学意义.在停药40周时,A、B、C、D组与E组复发率比较差异有统计学意义.在停药56周、72周时,D组与A、B组复发率比较差异也出现统计学意义.结论 口服特比萘芬2周联合外用1%联苯苄唑乳膏2周治疗足癣的有效率和真菌学疗效最高,复发率最低.
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| 关 键 词： | 足癣 特比萘芬 联苯苄唑乳膏 疗效 复发率 |
A long-term clinical study on oral terbinafine combined with topical bifonazole cream for tinea pedis treatment |
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| ZHANG Ya-jie,LI Qing.A long-term clinical study on oral terbinafine combined with topical bifonazole cream for tinea pedis treatment[J].Chinese JOurnal of Mycology,2011,6(4):220-224. |
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| Authors: | ZHANG Ya-jie LI Qing |
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| Institution: | 1.Department of Dermatology,Shenzhen People′s Hospital,the Second Clinical Medical College,Jinan University,Shenzhen 518020;2.The Forth People′s Hospital of Shenzhen,Shenzhen 518033) |
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| Abstract: | Objective To find the best schedule for tinea pedis treatment.Methods A total of 250 patients with tinea pedis were divided into five groups: group A(oral terbinafine combined with 1% topical bifonazole cream for 1 week),group B(oral terbinafine for 1 week combined with 1% topical bifonazole cream for 2 weeks),group C(oral terbinafine for 2 weeks combined with 1% topical bifonazole cream for 1 week),group D(oral terbinafine combined with 1% topical bifonazole cream for 2 weeks),and group E(only 1% topical b... |
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| Keywords: | tinea pedis terbinafine bifonazole cream treatment relapse rate |
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