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Five Candidate Genes for Hamster Cardiomyopathy Did not Map to the Cardiomyopathy Locus by FISH Analysis |
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| Authors: | Takada Shuji; Okazaki Yasushi; Kamiya Mamoru; Ohsumi Tomoya; Nomura Osamu; Okuizumi Hisato; Sasaki Nobuya; Shibata Hideo; Mori Masayuki; Nishimura Masahiko; Muramatsu Masami; Hayashizaki Yoshihide; Matsuda Yoichi |
| Institution: | 1Genome Science Laboratory, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN) 3-1-1 Koyadai, Tsukuba, Ibaraki 305, Japan 2Institute for Experimental Animals, Hamamatsu University School of Medicine 3600 Handa-cho, Hamamatsu 431-31, Japan 3Laboratory of Animal Genetics, School of Agricultural Sciences, Nagoya University Chikusa, Nagoya, 464-01, Japan |
| Abstract: | The Syrian cardiomyopathic hamster (BIO14.6), that developsboth muscular dystrophy and progressive cardiomyopathy, is widelyused as an animal model of autosomal recessive cardiomyopathymimicking human hypertrophic cardiomyopathy, and five geneshave been proposed as strong candidates for the cause of cardiomyopathy.We recently mapped the cardiomyopathy locus of the hamster tothe centromeric region of chromosome 9qa2.1-b1 by constructionof a genetic linkage map of the Syrian hamster. Thus, we analyzedthe loci of the five candidate genes,  tropomyosin, cardiactroponin T, adhalin, calpain 3 and cardiac myosin binding protein-C,by the FISH method, and found that these genes were mapped onthe distal portion of chromosome 12qa5 and 4pa2 |
| Keywords: | cardiomyopathic hamster (BIO14 6) hypertrophic cardiomyopathy muscular dystrophy FISH chromosomal location |
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