The Cd technique identifies a specific structure related to centromeric function |
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Authors: | Simonetta Lambiase Paola Maraschio Orsetta Zuffardi |
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Institution: | (1) Istituto di Biologia Generale e Genetica Medica, C.P. 217, I-27100 Pavia, Italy |
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Abstract: | Summary The evidence that the Cd technique identifies the kinetochore was based on the finding that inactive centromeres are C-positive but Cd-negative. The identity between Cd-positivity and centromere function is now confirmed by the reverse procedure: a stable abnormal chromosome is consistently C-negative but Cd-positive at its single centromeric constriction. This demonstrates that the Cd dots are not a relic of C-banding but identify the active centromere. |
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