miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway |
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Authors: | Yan Cheng Yang Li Dong Liu Rong Zhang Jun Zhang |
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Institution: | 1. Department of Digestive Diseases, The Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, PR China;2. Department of Otolaryngology-head and neck surgery, The Second Affiliated Hospital, Medical School of Xi''an Jiaotong University, Xi''an, Shaanxi 710061, PR China |
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Abstract: | The discovery of microRNAs (miRNAs) provided a new avenue for early diagnosis and treatment of GC. MiR-137 has been reported to be under-expressed and involved in various cell processes. However, the role of miR-137 in GC is less known. In this study, we show that miR-137 is under-expressed in GC and functions as a tumor suppressor through targeting Cyclooxygenase-2 (Cox-2), which subsequently suppresses the activation of PI3K/AKT signaling pathway both in vitro and in vivo. Moreover, restored Cox-2 expression partially abolished the tumor suppressive effects of miR-137 in GC cells, suggesting miR-137 may suppress GC carcinogenesis by targeting Cox-2. |
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Keywords: | Stomach neoplasm miR-137 Cyclooxygenase-2 PI3K/AKT signaling pathway Xenograft tumor |
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