MicroRNA-145 directly targets the insulin-like growth factor receptor I in human bladder cancer cells |
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| Authors: | Zhaowei Zhu Tianyuan Xu Li Wang Xianjin Wang Shan Zhong Chen Xu Zhoujun Shen |
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| Institution: | 1. Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China;2. Department of Embryology and Histology, Shanghai Jiaotong University School of Medicine, Shanghai, China;3. Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China |
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| Abstract: | The insulin-like growth factor receptor I (IGF-IR) is a proto-oncogene with potent mitogenic and antiapoptotic activities. It has been reported that expression of IGF-IR is up-regulated in bladder cancer. Here, we assessed whether microRNA-145 (miR-145) regulates IGF-IR expression in bladder cancer. In our study, miR-145 was shown to directly target IGF-IR 3′-untranslated region (UTR) in human bladder cancer cells. Small interfering RNA (siRNA)- and miR-145-mediated IGF-IR knockdown experiments revealed that miR-145 promotes cell apoptosis, and suppresses cell proliferation and migration through suppression of IGF-IR expression. Taken together, our data suggest that miR-145 may inhibit bladder cancer initiation by affecting IGF-IR signaling. |
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| Keywords: | Bladder cancer miR-145 IGF-IR Apoptosis Proliferation Migration |
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