Identification and comparative analysis of a genomic island in Mycobacterium avium subsp. hominissuis |
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| Authors: | Annesha Lahiri,Andrea Sanchini,Torsten Semmler,Hubert Schä fer,Astrid Lewin |
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| Affiliation: | 1. Robert Koch Institute, Division 16 Mycotic and Parasitic Agents and Mycobacteria, Nordufer 20, 13353 Berlin, Germany;2. Freie Universität Berlin, Centre for Infection Medicine, Institute of Microbiology and Epizootics, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany |
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| Abstract: | Mycobacterium avium subsp. hominissuis (MAH) is an environmental bacterium causing opportunistic infections. The objective of this study was to identify flexible genome regions in MAH isolated from different sources. By comparing five complete and draft MAH genomes we identified a genomic island conferring additional flexibility to the MAH genomes. The island was absent in one of the five strains and had sizes between 16.37 and 84.85 kb in the four other strains. The genes present in the islands differed among strains and included phage- and plasmid-derived genes, integrase genes, hypothetical genes, and virulence-associated genes like mmpL or mce genes. |
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| Keywords: | GI, genomic island LSP, Long Sequence Polymorphism MAA, Mycobacterium avium subsp. avium MAC, Mycobacterium avium complex MAH, Mycobacterium avium subsp. hominissuis MAP, Mycobacterium avium subsp. paratuberculosis MAS, Mycobacterium avium subsp. silvaticum SNP, Single Nucleotide Polymorphism |
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