Aim24 stabilizes respiratory chain supercomplexes and is required for efficient respiration |
| |
Authors: | Markus Deckers Martina BalleiningerMilena Vukotic Katharina RömplerBettina Bareth Lisa JurisJan Dudek |
| |
Institution: | Department of Cellular Biochemistry, University of Göttingen, D-37073 Göttingen, Germany |
| |
Abstract: | The mitochondrial respiratory chain is essential for the conversion of energy derived from the oxidation of metabolites into the membrane potential, which drives the synthesis of ATP. The electron transporting complexes bc1 complex and the cytochrome c oxidase assemble into large supercomplexes, allowing efficient energy transduction. Currently, we have only limited information about what determines the structure of the supercomplex. Here, we characterize Aim24 in baker’s yeast as a protein, which is integrated in the mitochondrial inner membrane and is required for the structural integrity of the supercomplex. Deletion of AIM24 strongly affects activity of the respiratory chain and induces a growth defect on non-fermentable medium. Our data indicate that Aim24 has a function in stabilizing the respiratory chain supercomplexes. |
| |
Keywords: | Metabolism Mitochondria Membrane protein Aim24 Respiration Supercomplex |
本文献已被 ScienceDirect 等数据库收录! |