MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2 |
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Authors: | Zhoufang Mei Yanchao He Jingjing Feng Jindong ShiYong Du Ling QianQihui Huang Zhijun Jie |
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Institution: | Department of Respiratory Medicine, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China |
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Abstract: | The dysregulation of microRNAs (miRNAs) is crucially implicated in the development of various cancers. In this study, we explored the biological role of miR-141 in non-small cell lung cancer (NSCLC). miR-141 expression was significantly up-regulated in NSCLC tissues, and its overexpression accelerated NSCLC cell proliferation in vitro and tumor growth in vivo. We subsequently identified the antagonists of PI3K/AKT signaling, PH domain leucine-rich-repeats protein phosphatase 1 (PHLPP1) and PHLPP2, as direct targets of miR-141. Re-introduction of PHLPP1 and PHLPP2 abrogated miR-141-induced proliferation of NSCLC cells. Together, the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis, and provide potential therapeutic targets for NSCLC treatment. |
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Keywords: | MicroRNA-141 PH domain leucine-rich-repeats protein phosphatase 1 PH domain leucine-rich-repeats protein phosphatase 2 Non-small cell lung cancer Proliferation |
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