Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21 |
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| Authors: | Sik-Won Choi Hye Kyoung Shin Hsin-Fang Yang-Yen Myeung Su Lee Chang Hoon Lee Sang-Joon Park Kwang-Jin Kim Kyunglim Lee Seong Hwan Kim |
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| Affiliation: | 1. Laboratory of Translational Therapeutics, Pharmacology Research Center, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea;2. Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea;3. Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan;4. Division of Rheumatology, Department of Internal Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea;5. Department of Histology, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea;6. Department of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of Korea |
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| Abstract: | Translationally-controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss-of-function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP-mediated phenotypic induction of osteoclast differentiation accompanied by p21 down-regulation, attenuating the proliferation of osteoclast precursor cells. |
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| Keywords: | TCTP, translationally-controlled tumor protein BMD, bone mineral density M-CSF, macrophage colony-stimulating factor RANKL, receptor activator of nuclear factor-kB ligand BMMs, bone marrow-derived macrophages TRAP, tartrate-resistant acid phosphatase MNC, multinucleated osteoclast cells BV/TV, bone volume/tissue volume Tb.N, number of trabeculae Tb.Sp, trabecular separation |
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