| 沙门菌致病岛2 Ⅲ型分泌系统研究进展 |
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| 引用本文： | 殷俊磊,李求春,焦新安. 沙门菌致病岛2 Ⅲ型分泌系统研究进展[J]. 微生物学报, 2016, 56(4): 561-569 |
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| 作者姓名： | 殷俊磊 李求春 焦新安 |
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| 作者单位： | 扬州大学江苏省人兽共患病学重点实验室, 江苏省动物重要疫病与人兽共患病防控协同创新中心, 江苏 扬州 225009,扬州大学江苏省人兽共患病学重点实验室, 江苏省动物重要疫病与人兽共患病防控协同创新中心, 江苏 扬州 225009,扬州大学江苏省人兽共患病学重点实验室, 江苏省动物重要疫病与人兽共患病防控协同创新中心, 江苏 扬州 225009 |
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| 基金项目： | 国家自然科学基金(31230070,31201905);国家公益性行业(农业)科研专项(201403054);江苏省普通高校研究生科研创新计划项目(CXZZ13_0917);江苏省优势学科项目 |
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| 摘 要： | 沙门菌(Salmonella)是革兰氏阴性的兼性胞内菌,可引起其广泛宿主的一系列疾病,严重时可导致全身性感染,威胁生命安全。沙门菌致病岛2(SPI2)是与沙门菌全身性感染密切相关的重要毒力基因簇,其编码的Ⅲ型分泌系统2(T3SS2)在沙门菌侵入宿主细胞后开始组装合成,经该装置分泌的多种效应蛋白对沙门菌在宿主细胞内的生存和增殖起着重要作用。近些年来,与沙门菌T3SS2相关的研究一直都是病原微生物领域关注的焦点之一。本文简要综述了SPI2的基因特征、SPI2基因表达的调控、T3SS2的结构和组成、T3SS2的效应蛋白及与T3SS2相关的疫苗研究等方面的主要研究进展。
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| 关 键 词： | 沙门菌 沙门菌致病岛2 Ⅲ型分泌系统 |
| 收稿时间： | 2015-06-11 |
| 修稿时间： | 2015-08-21 |
Advances in Salmonella pathogenicity island 2 type III secretion system-A review |
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| Junlei Yin,Qiuchun Li and Xin''an Jiao. Advances in Salmonella pathogenicity island 2 type III secretion system-A review[J]. Acta microbiologica Sinica, 2016, 56(4): 561-569 |
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| Authors: | Junlei Yin Qiuchun Li Xin''an Jiao |
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| Affiliation: | Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, Jiangsu Province, China,Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, Jiangsu Province, China and Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, Jiangsu Province, China |
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| Abstract: | Salmonella is a Gram-negative facultative intracellular pathogen that can infect vast array of hosts and cause a series of diseases, sometimes even life-threatening systemic diseases. As an indispensable virulence determinant associated with the systemic infections, Salmonella pathogenicity island 2 (SPI2) encodes type III secretion system 2 (T3SS2) which is induced after invasion, and the T3SS2 secreted effectors are essential for Salmonella to survive and replicate inside various cell types. In recent years, this issue remains the focus of pathogenic research. This review focuses on the aspects of gene characterization of SPI2, regulation of SPI2 gene expression, the structure and assembly of T3SS2, the T3SS2 effectors and some vaccine candidates associated with T3SS2 to present the current understanding of Salmonella T3SS2. |
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| Keywords: | Salmonella Salmonella pathogenicity island 2 type III secretion system |
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