A simple quantitative chiral analysis of amino acid esters by fluorine‐19 nuclear magnetic resonance using the modified James–Bull method |
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| Authors: | Naoto Hamaguchi Yuta Okuno Yohei Oe Tetsuo Ohta |
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| Abstract: | A simple chiral analysis of amino acid esters by fluorine‐19 nuclear magnetic resonance (19F NMR) through the modified James–Bull method is described. Thus, amino acid ester acid salt was treated with 5‐fluoro‐2‐formylphenylboronic acid and (S)‐BINOL in the presence of triethylamine (TEA) and MS4A for 10 minutes. The reaction mixture was analysed by 19F NMR directly to afford good quantifications. |
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| Keywords: | 19F NMR amino acids James‐bull assembly quantification |
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