Method for determination of optical purity of 2‐arylpropanoic acids using urea derivatives based on a 1,1′‐binaphthalene skeleton as chiral NMR solvating agents: Advantages and limitations thereof |
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Authors: | Petra Cuínov Peter Hjek Kristýna Jank Roman Holakovský |
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Institution: | Petra Cuřínová,Peter Hájek,Kristýna Janků,Roman Holakovský |
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Abstract: | Five optically active urea derivatives ( 1 ‐ 5 ) were used as NMR solvating agents for analysis of the optical purity of different 2‐arylpropanoic acids commonly used as nonsteroidal anti‐inflammatory drugs. These novel chiral solvating agents were more efficient at discriminating the respective enantiomers of targets than the chiral solvating agents known so far, without the need to add a base for achieving the signal splitting. The advantages and limits of the use of these novel chiral solvating agents were studied. |
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Keywords: | arylpropanoic acids binaphthalene chiral solvating agent nonsteroidal anti‐inflammatory drugs urea |
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