Whole body elimination routes of gold in humans after a single-dose application of the antirheumatic Auranofin |
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Authors: | Schnier C. Benn H. P. |
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Affiliation: | 1.Institute of Physics, GKSS Research Centre Geesthacht, Max-Planck-Str., D-2054, Geesthacht, FRG ;2.Second Department of Internal Medicine, University of Kiel, Metzstr. 53-57, D-2300, Kiel, FRG ; |
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Abstract: | After removal of the gallbladder (cholecystectomy) 7 patients were administered the antirheumatic agent Auranofin in its commercially available tablet form (Ridaura) 3 d postoperative. The single dose consisted of 5 tablets (4.35 mg of gold). Gold was determined in samples of blood, plasma, urine, bile, and feces (1–2 mL and 2.5 g, respectively). The specimens were drawn 10 min to 8 d p.a. and on d 14 p.a. The determinations were performed by instrumental neutron activation analysis (INAA). The limit of detection was less than 1 ng of gold. The courses of the mean gold concentrations show maxima after 1.9 h in blood and plasma, and after 16 h in urine and bile. The mean half-lives (terminal phases) are 7.6 d (blood), 23 d (plasma), and 6.5 d (bile). |
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Keywords: | KeywordHeading" >Index Entries Auranofin gold in blood, plasma, bile, urine, feces instrumental neutron activation analysis (INAA) |
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