Is the expression of kinin B1 receptor related to intrahepatic vascular response? |
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| Authors: | Marcia R Nagaoka Luciana Gomiero Felipe O Teixeira Fernando G Agostino José Eduardo P Pouza Priscila Mimary Durval R Borges Maria Kouyoumdjian |
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| Institution: | 1. Department of Biochemistry, Laboratory of Experimental Hepatology, Universidade Federal de São Paulo (UNIFESP) Rua Botucatu, 862 - Edifício Jose Leal Prado 04023-901 São Paulo, Brazil;2. Department of Medicine, Laboratory of Experimental Hepatology, Universidade Federal de São Paulo (UNIFESP) 04023-900, São Paulo, Brazil |
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| Abstract: | Bradykinin elicits an intrahepatic vascular response (IHVR) mediated by the constitutive B2 receptor (B2R). The biological effects of kinins may also be mediated by the inducible B1 receptor (B1R). Aim: To verify if the hepatic B1R expression modulates IHVR to kinins. Method: We evaluated the ability of bradykinin and B1R agonists to elicit an IHVR in normal rats and in those submitted to acute or chronic inflammatory stimuli, fibrosis, cirrhosis, or hepatic regeneration. Results: Bradykinin-induced IHVR was similar in all groups. B1R agonists did not elicit in any of them either a hypertensive or a hypotensive response. B1 receptor induction was observed in all experimental groups (Western blot), except for the acute inflammatory group. Conclusion: B1R hepatic expression did not modulate IHVR to kinins. |
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| Keywords: | Bradykinin Des-Arg9-bradykinin B1 receptor Portal hypertension Liver fibrosis |
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