Evolution of the NANOG pseudogene family in the human and chimpanzee genomes |
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| Authors: | Daniel J Fairbanks Peter J Maughan |
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| Institution: | (1) Department of Plant and Animal Sciences, Brigham Young University, 84602 Provo, UT, USA |
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| Abstract: | Background The NANOG gene is expressed in mammalian embryonic stem cells where it maintains cellular pluripotency. An unusually large family of
pseudogenes arose from it with one unprocessed and ten processed pseudogenes in the human genome. This article compares the
NANOG gene and its pseudogenes in the human and chimpanzee genomes and derives an evolutionary history of this pseudogene family. |
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