Variations in gene organization and DNA uptake signal sequence in the folP region between commensal and pathogenic Neisseria species |
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| Authors: | Yvonne Qvarnstrom Gote Swedberg |
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| Affiliation: | (1) Department of Medical Biochemistry and Microbiology, Uppsala University, PO Box 582, SE-751 23 Uppsala, Sweden;(2) Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, mail stop F36, 4770, Buford Highway, 30341 Atlanta, GA, USA |
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| Abstract: | Background Horizontal gene transfer is an important source of genetic variation among Neisseria species and has contributed to the spread of resistance to penicillin and sulfonamide drugs in the pathogen Neisseria meningitidis. Sulfonamide resistance in Neisseria meningitidis is mediated by altered chromosomal folP genes. At least some folP alleles conferring resistance have been horizontally acquired from other species, presumably from commensal Neisseriae. In this work, the DNA sequence surrounding folP in commensal Neisseria species was determined and compared to corresponding regions in pathogenic Neisseriae, in order to elucidate the potential for inter-species DNA transfer within this region. |
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