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Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals |
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| Authors: | Grahame Mckenzie George Ward Yvette Stallwood Emmanuel Briend Sofia Papadia Andrew Lennard Martin Turner Brian Champion Giles E Hardingham |
| Affiliation: | (1) Lorantis Ltd., 410 Cambridge Science Park, Cambridge, CB4 0PE, UK;(2) Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh, EH9 1QH, UK;(3) The Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB2 4AT, UK;(4) Inion Ltd, Unit 9B, Cambridge Science Park, Cambridge, CB4 0FG, UK |
| Abstract: | BackgroundNotch plays a wide-ranging role in controlling cell fate, differentiation and development. The PI3K-Akt pathway is a similarly conserved signalling pathway which regulates processes such as differentiation, proliferation and survival. Mice with disrupted Notch and PI3K signalling show phenotypic similarities during haematopoietic cell development, suggesting functional interaction between these pathways. |
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