Frequency of Ag-stained nucleolus organizer regions in the acrocentric chromosomes of man |
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| Authors: | A V Mikelsaar M Schmid W Krone H G Schwarzacher W Schnedl |
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| Institution: | (1) Histologisch-Embryologisches Institut of the University of Vienna, Vienna, Austria;(2) Institut für Humangenetik of the University of Ulm, Germany;(3) Present address: Central Medical Research Laboratory, Tartu State University, USSR |
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| Abstract: | Summary The Ag-stainability of the nucleolus organizer region (NOR) was studied in the acrocentric chromosomes identified by Q-banding of cultured lymphocytes in 51 karyotypically normal persons (31 males and 20 females). A consistent pattern of Ag-positive NORs was found in each individual. Ninety percent of the individuals have a modal number of 8–10 Ag-positive NORs per cell. The frequency of Ag-positive NORs is similar in all five acrocentrics. A statistically nonsignificant lower frequency is found in chromosome 22. Ag-negative NORs on both homologues were found in four cases. The observed frequency distribution of individuals with homozygous NOR-positive, heterozygous, and homozygous negative acrocentric chromosomes was in accordance with the Hardy-Weinberg law in all five pairs of the acrocentric chromosomes as well as in total. No sex difference was observed in our material.A.-V. Mikelsaar is visiting exchange scientist of the Österreichische Bundesministerium für Wissenschaft und Forschung |
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