Enzymatic asymmetric synthesis by decarboxylases |
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Authors: | Ward O P Singh A |
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Affiliation: | Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. opward@sciborg.uwaterloo.ca |
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Abstract: | Decarboxylation reactions using microbial cells or enzymes are increasingly being used for the synthesis of enantiomerically pure compounds because of their high degree of regio- and stereo-specificity. Pyruvate decarboxylase, benzoylformate decarboxylase and phenylpyruvate decarboxylase enzymes are capable of acyloin-type condensation reactions leading to formation of chiral alpha-hydroxy ketones, which are versatile building blocks in the pharmaceutical and chemical industries. Availability of three-dimensional structures of some decarboxylases in recent years has facilitated understanding of reaction mechanisms and the creation of mutants with enhanced activity and stability. |
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Keywords: | biotransformation decarboxylation decarboxylase acyloin-type condensation a-hydroxy |
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