HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes |
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| Authors: | Doria-Rose Nicole A Louder Mark K Yang Zhongjia O'Dell Sijy Nason Martha Schmidt Stephen D McKee Krisha Seaman Michael S Bailer Robert T Mascola John R |
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| Institution: | Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. |
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| Abstract: | HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding site and V1V2 region displayed no in vitro cross-competition and displayed additive, though not synergistic, neutralization activity. Predicted neutralization coverage of a combination of two MAbs reached 97% on a 208-isolate panel. |
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