Amphotericin B stimulates secretion of beta-hexosaminidase from mouse adherent spleen cells. |
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| Authors: | T Beccari R Mazzolla E Constanzi A Datti R Barluzzi F Bistoni A Orlacchio |
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| Institution: | Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Perugia, Italy. |
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| Abstract: | Secretion of the lysosomal enzyme hexosaminidase is induced by amphotericin B in mouse spleen adherent cells that show a significant increase in their candidacidal activity. The stimulation of beta-hexosaminidase is both time and dose dependent. Amphotericin B treatment did not change hexosaminidase expression that is represented mainly by "A-type" hexosaminidase in macrophages, on the basis of its biochemical properties. |
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