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The gene for human chromogranin A (CgA) is located on chromosome 14 |
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| Authors: | S S Murray L L Deaven D W Burton D I O'Connor P L Mellon L J Deftos |
| Affiliation: | 1. School of Public Administration, Guangdong University of Finance and Economics, Guangzhou 510320, Guangdong Province, China;2. School of Geography & Ocean Science, Nanjing University, Nanjing 210023, Jiangsu Province, China;3. Department of Philosophy, Nanjing University, Nanjing 210023, Jiangsu Province, China;2. Grupo Fleury, São Paulo, SP, Brazil;3. Escola Paulista de Medicina – Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil;4. Diagnósticos da América S.A., São Paulo, SP, Brazil;1. Laboratory of Translational Research, Azienda USL– IRCCS di Reggio Emilia, Reggio Emilia, Italy |
| Abstract: | Chromogranin A (CgA) is a protein that is present in most neuroendocrine tissues and is co-secreted with their resident hormones. We have assigned the CgA gene to human chromosome 14 by hybridization of a CgA cDNA probe cloned from a cDNA library of human medullary thyroid carcinoma cells to spots of individual human chromosomes flow-sorted onto nitrocellulose filters. Southern analysis of human genomic DNA with the same probe revealed only 1-3 restriction bands. These studies indicate that the CgA gene is probably single copy and not a member of a dispersed, multigene family. The CgA gene is not co-localized with the genes of any of the CgA-associated hormones. |
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