Novel subdomains of the mouse olfactory bulb defined by molecular heterogeneity in the nascent external plexiform and glomerular layers |
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| Authors: | Eric O Williams Yuanyuan Xiao Heather M Sickles Paul Shafer Golan Yona Jean YH Yang David M Lin |
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| Affiliation: | (1) Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA;(2) Department of Biostatistics, University of California San Francisco, San Francisco, CA, USA;(3) Department of Computer Science, Cornell University, Ithaca, NY, USA;(4) Department of Computer Science, Technion Institute, Israel;(5) School of Mathematics and Statistics, University of Sydney, Sydney, Australia |
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| Abstract: | Background In the mouse olfactory system, the role of the olfactory bulb in guiding olfactory sensory neuron (OSN) axons to their targets is poorly understood. What cell types within the bulb are necessary for targeting is unknown. What genes are important for this process is also unknown. Although projection neurons are not required, other cell-types within the external plexiform and glomerular layers also form synapses with OSNs. We hypothesized that these cells are important for targeting, and express spatially differentially expressed guidance cues that act to guide OSN axons within the bulb. |
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