| 幽门螺杆菌空泡毒素研究进展 |
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| 引用本文： | 刘纯杰,陶好霞,张兆山.幽门螺杆菌空泡毒素研究进展[J].生物技术通讯,2001,12(2):132-134. |
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| 作者姓名： | 刘纯杰 陶好霞 张兆山 |
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| 作者单位： | 军事医学科学院生物工程研究所 |
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| 摘 要： | 幽门螺杆菌空泡毒素是该菌产生的已知其它细菌毒素无明显源性的唯一蛋白毒素。该毒素是幽门螺杆菌重要的毒力致病因子，它的产生与感染胃肠上皮损伤和溃疡形成密切相关。本就幽门螺杆菌空泡毒素的结构与功能研究进展以及在未来免疫预防与免疫治疗中的作用进行了阐述。
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| 关 键 词： | 幽门螺杆菌 空泡毒素 致病因子 |
| 修稿时间： | 2000年10月20 |
The vacuolating cytotoxin of Helicobacter pylori |
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| LIU Chun-jie,TAO Hao-Xia,ZHANG Zhao-shan.The vacuolating cytotoxin of Helicobacter pylori[J].Letters in Biotechnology,2001,12(2):132-134. |
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| Authors: | LIU Chun-jie TAO Hao-Xia ZHANG Zhao-shan |
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| Abstract: | The vacuolating cytotoxin is a unique proteinous cytotoxin producted by H. pylori that showed no striking primary sequence homology with other known baterial toxins. The cytotoxin is an important fator in the pathogenesis of H. pylori, which induces vacuolation of epithelial cells and plays an important role in gastric epithelial necrosis and peptic ulceration. In the paper, the progress on structure and function of the vacuolating cytotoxin of H. pylori and the roles of the H. pylori vacuolating cytotoxin in the future immunoprophylaxis and immunotherapy were reviewed. |
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| Keywords: | Helicobacter pylori vacuolating cytotoxin |
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