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Loss of Hem1 disrupts macrophage function and impacts migration,phagocytosis, and integrin-mediated adhesion
Authors:Stephanie Stahnke  Hermann Döring  Charly Kusch  David J.J. de Gorter  Sebastian Dütting  Aleks Guledani  Irina Pleines  Michael Schnoor  Michael Sixt  Robert Geffers  Manfred Rohde  Mathias Müsken  Frieda Kage  Anika Steffen  Jan Faix  Bernhard Nieswandt  Klemens Rottner  Theresia E.B. Stradal
Affiliation:1. Department of Cell Biology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany;2. Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany;3. Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany;4. Institute of Molecular Cell Biology, Westphalian Wilhelms University Münster WWU, Münster, Germany;5. Department for Molecular Biomedicine, Centre for Investigation and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN), 07360 Mexico City, Mexico;6. Institute of Science and Technology IST Austria, Klosterneuburg, Austria;7. Genome Analytics Group, Helmholtz Center for Infection Research HZI, Braunschweig, Germany;8. Central Facility for Microscopy, Helmholtz Center for Infection Research HZI, Braunschweig, Germany;9. Institute for Biophysical Chemistry, Hannover Medical School MHH, 30625 Hannover, Germany
Abstract:
Keywords:Hem1  WAVE regulatory complex  WRC  integrin  phagocytosis  adhesion  protrusion  macrophage  knockout  rescue
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