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Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19
Authors:Madhan Jeyaraman  Albin John  Santhosh Koshy  Rajni Ranjan  Talagavadi Channaiah Anudeep  Rashmi Jain  Kumari Swati  Niraj Kumar Jha  Ankur Sharma  Kavindra Kumar Kesari  Anand Prakash  Parma Nand  Saurabh Kumar Jha  P. Hemachandra Reddy
Abstract:The coronavirus disease 2019 (COVID-19) has been threatening the globe since the end of November 2019. The disease revealed cracks in the health care system as health care providers across the world were left without guidelines on definitive usage of pharmaceutical agents or vaccines. The World Health Organization (WHO) declared COVID-19 as a pandemic on the 11th of March 2020. Individuals with underlying systemic disorders have reported complications, such as cytokine storms, when infected with the virus. As the number of positive cases and the death toll across the globe continue to rise, various researchers have turned to cell based therapy using stem cells to combat COVID-19. The field of stem cells and regenerative medicine has provided a paradigm shift in treating a disease with minimally invasive techniques that provides maximal clinical and functional outcome for patients. With the available evidence of immunomodulatory and immune-privilege actions, mesenchymal stem cells (MSCs) can repair, regenerate and remodulate the native homeostasis of pulmonary parenchyma with improved pulmonary compliance. This article revolves around the usage of novel MSCs therapy for combating COVID-19.
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