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Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation
Authors:Kazuhiko SK Uchida  Minji Jo  Kota Nagasaka  Motoko Takahashi  Norihisa Shindo  Katsushi Shibata  Kozo Tanaka  Hiroshi Masumoto  Tatsuo Fukagawa  Toru Hirota
Institution:1. Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan;2. Division of Functional Genomics, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan;3. Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;4. Laboratory of Chromosome Engineering, Kazusa DNA Research Institute, Kisarazu, Japan;5. Laboratory of Chromosome Biology, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
Abstract:
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  • Keywords:anaphase bridges  cancer  chromosomal instability  metaphase-to-anaphase transition  mitotic checkpoint  CENP-T  Knl1  Mps1  PP1
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