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A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel
Authors:Chang Liu  Rebecca Reese  Simon Vu  Lionel Rougé  Shannon D. Shields  Satoko Kakiuchi-Kiyota  Huifen Chen  Kevin Johnson  Yu Patrick Shi  Tania Chernov-Rogan  Demi Maria Zabala Greiner  Pawan Bir Kohli  David Hackos  Bobby Brillantes  Christine Tam  Tianbo Li  Jianyong Wang  Brian Safina  Jun Chen
Affiliation:1. Department of Biochemical Cellular Pharmacology, Genentech, 103 DNA Way, South San Francisco, CA 94080, USA;2. Department of Neuroscience, Genentech, 103 DNA Way, South San Francisco, CA 94080, USA;3. Department of Physiology and Membrane Biology, University of California, Davis, 4145 Tupper Hall, Davis, CA 95616, USA;4. Department of Structural Biology, Genentech, 103 DNA Way, South San Francisco, CA 94080, USA;5. Department of Safety Assessment, Genentech, 103 DNA Way, South San Francisco, CA 94080, USA;6. Department of Discovery Chemistry, Genentech, 103 DNA Way, South San Francisco, CA 94080, USA;7. Department of DMPK, Genentech, 103 DNA Way, South San Francisco, CA 94080, USA;8. Department of Biomolecular Resources, Genentech, 103 DNA Way, South San Francisco, CA 94080, USA
Abstract:
Keywords:TRPA1  covalent  non-covalent  ion channel  biased agonism  cryo-EM  pain  drug discovery
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