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The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability
Authors:Federica Polverino  Francesco D Naso  Italia A Asteriti  Valentina Palmerini  Divya Singh  Davide Valente  Alexander W Bird  Alessandro Rosa  Marina Mapelli  Giulia Guarguaglini
Institution:1. Institute of Molecular Biology and Pathology, National Research Council of Italy, c/o Department of Biology and Biotechnology, Sapienza University of Rome, Via degli Apuli 4, 00185 Rome, Italy;2. Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20141 Milan, Italy;3. Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany;4. Center for Life Nano Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy;5. Department of Biology and Biotechnology “C. Darwin,” Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Abstract:
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  • Keywords:mitosis  Aurora-A/TPX2 complex  spindle orientation  microtubules  NuMA  cell division  cell cortex  spindle poles
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