Correlation between baseline 18F-FDG PET/CT features and pathological complete response after neoadjuvant chemotherapy in early triple negative breast cancer |
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| Authors: | C. Bouron C. Mathie O. Morel V. Seegers C. Guillerminet F. Lacoeuille A. Patsouris A. Testard |
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| Affiliation: | 1. Department of nuclear medicine, ICO Pays de Loire, 15, rue André-Boquel, 49055 Angers, France;2. Department of nuclear medicine, University Hospital of Angers, 4, rue Larrey, 49100 Angers, France;3. Department of medical oncology, ICO Pays de Loire, 15, rue André-Boquel, 49055 Angers, France;4. Research and statistics department, ICO Pays de Loire, 15, rue André-Boquel, 49055 Angers, France;5. Department of medical physics, ICO Pays de Loire, 15, rue André-Boquel, 49055 Angers, France;6. CRCINA, University of Nantes and Angers, INSERM UMR1232 équipe 17, 49055 Angers, France;7. INSERM UMR1232 équipe 12, 49055 Angers, France;1. Service de médecine nucléaire, hôpital militaire principal d’instruction de Tunis, Tunis, Tunisie;2. Service d’oto-rhino-laryngologie, hôpital militaire principal d’instruction de Tunis, Tunis, Tunisie;3. Faculté de médecine de Tunis, Tunis, Tunisie;1. Nuclear medicine department. Military Hospital of Tunis, Tunis, Tunisia;2. Otorhinolaryngology department. Military Hospital of Tunis, Tunis, Tunisia;3. Military Health Services Application School, Tunis,Tunisia;1. Nuclear medicine department, university hospital of Martinique, CHU de Pierre-Zobda-Quitman, CS 90632, 97261 Fort-de-France, Martinique;2. Physiology department, university hospital of Martinique, Fort-de-France, Martinique;3. INSERM U942, Paris-Diderot university, Paris, France;1. Département de médecine nucléaire, institut des radio isotopes, université Abdou-Moumouni, Niamey, Niger;2. Service de médecine nucléaire, CHU Bâb-El-Oued, Alger, Algérie;3. Service d’endocrinologie, de diabétologie et de nutrition, hôpital général de référence, Niamey, Niger;4. Service de médecine interne, hôpital général de référence, Niamey, Niger;1. Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Cellular and Molecular Research Center, Yasouj University of Medical Sciences, Yasouj, Iran;3. Department of Biology, Faculty of Basic Sciences, Yasouj University, Yasouj, Iran |
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| Abstract: | Aim of the studyTo evaluate correlation between metabolic and textural parameters on baseline 18F-FDG PET/CT and pathological response after neoadjuvant chemotherapy in non-metastatic triple negative breast cancer (TNBC).MethodsAll consecutive non-metastatic TNBC women treated by neoadjuvant chemotherapy followed by breast surgery who underwent 18F-FDG PET/CT examination at diagnosis between 2012 and 2018 were retrospectively included. Metabolic parameters (SUVmax, SUVmean, SUVpeak, MTV, TLG) of the primary tumour and lymph nodes, and textural features (entropy, homogeneity, SRE, LRE, LGZE, HGZE) of the primary tumour were collected. Pathological response was defined according to Sataloff classification.ResultsSeventy-four patients were enrolled. In univariate analysis, metabolic and textural features of the primary breast lesion or metabolic parameters of regional lymph nodes were not predictive of pathological complete response after neoadjuvant chemotherapy.ConclusionMetabolic and textural features of baseline PET/CT do not seem to predict pathological response after neoadjuvant chemotherapy in non-metastatic triple negative breast cancer. |
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| Keywords: | PET/CT Triple negative breast cancer Neoadjuvant chemotherapy Pathological response Textural analysis TEP-TDM Cancer du sein triple négatif Chimiothérapie néoadjuvante Réponse histologique Analyse de texture |
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