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EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas
Authors:William Hill  Andreas Zaragkoulias  Beatriz Salvador-Barbero  Geraint J. Parfitt  Markella Alatsatianos  Ana Padilha  Sean Porazinski  Thomas E. Woolley  Jennifer P. Morton  Owen J. Sansom  Catherine Hogan
Affiliation:1. European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK;2. School of Optometry & Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4HQ, UK;3. Faculty of Medicine, St Vincent’s Clinical School, University of New South Wales, Sydney, Australia;4. School of Mathematics, Cardiff University, Senghennydd Road, Cardiff CF24 4AG, UK;5. CRUK Beatson Institute, Glasgow G61 1BD, UK;6. Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK
Abstract:
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  • Keywords:oncogenic KRAS  cell competition  pancreas  EphA2  pancreatic cancer  epithelial tissue  homeostasis  E-cadherin  PanINs  early tumorigenesis
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