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A Causal Role for the Pedunculopontine Nucleus in Human Instrumental Learning

Authors:	Vasilisa Skvortsova Stefano Palminteri Anne Buot Carine Karachi Marie-Laure Welter David Grabli Mathias Pessiglione

Affiliation:	1. Motivation, Brain and Behavior (MBB) laboratory, Paris Brain Institute (ICM), Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France;2. INSERM Unit 1127, CNRS Unit 7225, Sorbonne Universités (SU), Paris 75005, France;3. Laboratoire de Neurosciences Cognitives et Computationnelles, Département d’Etudes Cognitives, Ecole Normale Supérieure, Paris 75005, France;4. INSERM Unit 960, Université de Paris Sciences et Lettres (UP), 75005 Paris, France;5. Max Planck UCL Center for Computational Psychiatry and Aging, London WC1B 5EH, UK;6. Neurology and Neurosurgery department, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France;7. Neurophysiology Department, Hôpital Universitaire de Rouen, 76000 Rouen, France

Abstract:

Keywords:	decision making reinforcement learning reward prediction error computational modeling deep-brain stimulation local field potentials low-frequency oscillations pedunculopontine nucleus dopamine Parkinson disease
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