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UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
Authors:Kejing Zhang  Ailian Wang  Keke Zhong  Shuyuan Qi  Chen Wei  Xiaoqiu Shu  Wen-Yo Tu  Wentao Xu  Congcong Xia  Yatao Xiao  Aizhong Chen  Lei Bai  Jianmin Zhang  Benyan Luo  Wenyuan Wang  Chengyong Shen
Affiliation:1. Department of Neurobiology, The First Affiliated Hospital, Institute of Translational Medicine, School of Medicine, Zhejiang University, Zhejiang 310020, China;2. Department of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, School of Medicine, Zhejiang University, Zhejiang 310020, China;3. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;4. Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Abstract:
Keywords:amyotrophic lateral sclerosis  frontotemporal dementia  C9orf72  UBQLN2  HSP70  protein aggregation
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