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Nuclear Deformation Causes DNA Damage by Increasing Replication Stress
Authors:Pragya Shah  Chad M. Hobson  Svea Cheng  Marshall J. Colville  Matthew J. Paszek  Richard Superfine  Jan Lammerding
Affiliation:1. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA;2. Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA;3. Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA;4. Graduate Field of Biophysics, Cornell University, Ithaca, NY 14853, USA;5. Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA;6. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
Abstract:
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  • Keywords:nuclear mechanobiology  confined migration  DNA damage  cell compression  replication stress  nuclear deformation  cancer  nuclear envelope rupture  metastasis
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