| 天然大豆硒蛋白抗肿瘤作用研究 |
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| 引用本文： | 向天勇,吴永尧,陈建英. 天然大豆硒蛋白抗肿瘤作用研究[J]. 氨基酸和生物资源, 2005, 27(1): 10-12,21. DOI: 10.3969/j.issn.1006-8376.2005.01.003 |
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| 作者姓名： | 向天勇 吴永尧 陈建英 |
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| 作者单位： | 湖南农业大学生化与发酵工程实验室,长沙,410128;湖北民族学院生物技术研究所,恩施,445000 |
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| 基金项目： | 湖北省教育厅科研项目;99Z06; |
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| 摘 要： | 建立S180小鼠肿瘤动物模型,设计用不同的剂量处理,采用胃饲法补充从高硒土栽培大豆中提取的硒蛋白,研究大 豆硒蛋白的抗肿瘤活性。结果表明:在202.50μg(Se)/kg(体重)剂量范围内,大豆硒蛋白剂量增加可显著加强对S180肉瘤生 长的抑制,并能推迟S180肉瘤大鼠的死亡时间,补硒剂量在202.50μg/kg时对肿瘤生长抑制率达78%左右;相关指标显示大豆 硒蛋白可能是通过提高机体的抗氧化能力、调节免疫功能而发挥抗癌作用。
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| 关 键 词： | 大豆硒蛋白 S180肉瘤 肿瘤抑制 |
| 文章编号： | 1006-8376(2005)01-0010-03 |
Anticarcinogenic Activities of Soybean Selenoprotein |
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| XIANG Tian-yong,WU Yong-yao,CHENG Jian-ying. Anticarcinogenic Activities of Soybean Selenoprotein[J]. Amino Acids & Biotic Resources, 2005, 27(1): 10-12,21. DOI: 10.3969/j.issn.1006-8376.2005.01.003 |
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| Authors: | XIANG Tian-yong WU Yong-yao CHENG Jian-ying |
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| Affiliation: | XIANG Tian-yong 1,WU Yong-yao 1,CHENG Jian-ying 2 |
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| Abstract: | In an attempt to investigate the anticarcinogenic activities of soybean selenoprotein, we varied the dosage of soybean selenoprotein in mice S180-tumor model in which mice were stomach-fed the selenoprotein at level of 0.00μg/kg(Se/mice weight), 22.50μg/kg, 67.50μg/kg, 202.50μg/kg or 607.50μg/kg respectively. Our research showed that a dose-dependent cancer protection effect was expressed in rang of 22.5~202.5μg/kg in the diet. Total tumor growth was consistently reduced by 70~80% with 202.5μg/kg selenoprotein supplementation. Our data therefore implied that the oxidation prevention and immune adjusting might represent a mechanism of tumor suppression by soybean selenoprotein. |
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| Keywords: | soybean selenoprotein tumor S180 anticarcinogenic activity |
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