Uncovering novel cell cycle players through the inactivation of securin in budding yeast |
| |
| Authors: | Sarin Sumeet Ross Karen E Boucher Lorrie Green Yvette Tyers Mike Cohen-Fix Orna |
| |
| Affiliation: | The Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0840, USA. |
| |
| Abstract: | Budding yeast securin/Pds1p, an inhibitor of the anaphase activator separase/Esp1p, is involved in several checkpoint pathways and in promoting Esp1p's nuclear localization. Using a modified synthetic genetic array (SGA) screen for genes that become essential in the absence of Pds1p, we uncovered roles for uncharacterized genes in cell cycle processes, including Esp1p activation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
