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A rat mutation producing demyelination (dmy) maps to chromosome 17 |
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| Authors: | T. Kuramoto C. Sotelo N. Yokoi T. Serikawa E. Goñalons Sintes J. Cantó Martorell J. -L. Guénet |
| Affiliation: | 1. Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, 606-01, Sakyo-ku, Kyoto, Japan 2. INSERM U-106, Neuromorphologie, Développement-Evolution, H?pital de La Salpétrière, Boulevard de l’H?pital, 75651, Paris, Cedex 13, France 3. Departament de Biologia Cellular i de Fisiologia, Unitat de Fisiologia, Universit?t Autònoma de Barcelona, Bellaterra (Barcelona), Spain 4. Servei d’Estabulari, Universit?t Autònoma de Barcelona, Bellaterra (Barcelona), Spain 5. Institut Pasteur, Unité de Génétique des Mammifères, 25 Rue du Docteur Roux, F-75724, Paris Cedex 15, France |
| Abstract: | A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human. Received: 21 March 1996 / Accepted: 22 July 1996 |
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