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Intrinsic Temperature Sensitivity of Influenza C Virus Hemagglutinin-Esterase-Fusion Protein |
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| Authors: | Emi Takashita Yasushi Muraki Kanetsu Sugawara Hironobu Asao Hidekazu Nishimura Koji Suzuki Takashi Tsuji Seiji Hongo Yoshihiro Ohara Yoshihiro Kawaoka Makoto Ozawa Yoko Matsuzaki |
| Abstract: | Influenza C virus replicates more efficiently at 33°C than at 37°C. To determine whether hemagglutinin-esterase-fusion protein (HEF), a surface glycoprotein of influenza C virus, is a restricting factor for this temperature sensitivity, we analyzed the biological and biochemical properties of HEF at 33°C and 37°C. We found that HEF exhibits intrinsic temperature sensitivities for surface expression and fusion activity. |
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