Resveratrol-based cinnamic ester hybrids: synthesis,characterization, and anti-inflammatory activity |
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| Authors: | Ban-Feng Ruan Wei-Wei Ge Hui-Jie Cheng Hua-Jian Xu |
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| Institution: | School of Medical Engineering, Hefei University of Technology, Hefei, P. R. China |
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| Abstract: | Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway. |
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| Keywords: | Resveratrol derivatives cinnamic ester anti-inflammatory NF-κB signaling pathway molecular docking |
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